We know what it is like to be sick, to be disabled. Keeping You in the Family.
SARS-CoV-2 AND IVERMECTIN
CORONAVIRUS
Coronavirus (CoV) belong to a larger family Coronaviridae, within the order of Nidovirales. Several human pathogenic strains (HCoV) cause mainly respiratory disease, some cause a mild cold and others lead to severe infection. Fatal infections are caused mostly by SARS-CoV and MERS-CoV, having 10% and 39% mortality, respectively.
The SARS-CoV outbreak in 2002-2003 caused over 8,000 infections and 800 deaths; the 2012 Middle East respiratory syndrome (MERS) outbreak had about 2,500 cases and over 800 deaths; the World Health Organization daily report shows the current Coronavirus Disease 2019 (COVID-19) pandemic has over 15 million confirmed cases and over 600,000 deaths to date, as of July 26, 2020. Officially, the severe respiratory illness caused by the late December 2019 novel coronavirus is named Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2).
There is no effective treatment for COVID-19. A big effort to develop a vaccine requires significant time and safety testing, and not everyone will or can take a vaccination. If you are allergic to many medications, have had anaphylaxis or used an EpiPen for a swollen airway in the past, the vaccine may not be for you.
There must be other options for the general population, as well as at-risk first responders. For this reason, and to keep you out of the hospital, the Front Line COVID-19 Critical Care Alliance (FLCCC) has developed the I-MASK+ Protocol that uses Ivermectin to diminish the threat of COVID deaths.
Do you already know that you want to go on ivermectin?
YOUR FIRST STEP: To become a patient, click the link below for pre-registration.
Note that Dr. Margaret Aranda is one of eleven doctors in the US who writes prescriptions for ivermectin.
The Front Line COVID-19 Critical Care Alliance (FLCCC) has developed ivermectin protocols. Ivermectin is FDA approved for onchocerciasis and strongyloidiasis as an anti-parasitic drug.
Ivermectin is also known by the trade name Stromectol, and anti-parasitic medication in the class of antihelmintics. Generic ivermectin is known as Ivermectol, manufactured by Ochoa Laboratories Ltd. Ivecop is manufactured by Invida, and Scavista is manufactured by Zuvista (Zuventus Health Care Ltd).
Ivermectin comes in two strengths: 3 mg and 6 mg tablets.
Since all manufacturers are back-ordered, it is difficult to find a pharmacy that has ivermectin. Some pharmacies can compound it, creating capsules by hand out of ivermectin powder.
After invading a cell, the SARS-CoV-2 virus emits cargo or particles. These particles are actually an enzyme molecule that goes into the human nucleus by a protein complex and instructs it not to defend itself. The surrounding cells then are indefensible.
Thus, SARS-CoV-2 invades the nucleus, bypasses the body’s immune system and allows SARS-CoV-2 to run rampant through all cells.
The SARS-CoV-2 particles are brought into the nucleus by our bodies’ protein complex, and they enter the nucleus together.
While ivermectin has a very safe profile, common side effects of ivermectin include dizziness, headache, muscle pain, kidney and liver issues. Testicular dysfunction and infertility have been described. Those with allergies, asthma or liver disease should avoid it. If ivermectin kills internal parasites, dying microbes release toxins; some gastrointestinal complaints include nausea, soft stool, diarrhea and abdominal pain.
Some have reported drowsiness and take their dose at bedtime. Rarely, adverse side effects include seizure and hypotension. Do not operate machinery, drive or do any activity that requires alertness until you are sure you can safely do so. Limit alcohol consumption, especially if you have liver dysfunction. Note that ivermectin passes through breast milk.
Anecdotal reports state some patients have less pain from such conditions as spondylolysis and arthritis, as well as knee pain; both increased and decreased cervical lymph nodes have been reported.
If you are being treated for “river blindness” or onchocerciasis, reactions may include eye swelling, pain or redness; fever; joint pain; rash or itching; tender or swollen lymph nodes and vision changes.
Some take ivermectin with selenium and/or vitamin E to protect against hepatic and renal toxicity. Low selenium levels are associated with higher COVID-19 mortality, as selenium redistributes both Vitamin D and dexamethasone from liver storage to the immune system. Talk to your doctor about selenium supplementation, which may be preferred for those with low Vitamin D or liver dysfunction.
In parasitic worms, ivermectin paralyzes worm muscles, causing loss of breathing. It kills both endoparasites and ectoparasites, making it in the class of an endectocide. The mechanism of action is that ivermectin acts on the glutamate channels. In worms, ivermectin acts on these gated channels, acting in both nerves and muscles to cause uncontrolled chloride ions to flood into the cells, causing paralysis and death.
In SARS-CoV-2, ivermectin is not antiparasitic. It prevents a protein complex from carrying SARS-CoV-2 particles into the nucleus. If the virus cannot cross into the nucleus, it cannot instruct it to remain dormant.
Oppositely, ivermectin allows the nucleus to ramp up its defenses and fight SARS-CoV-2. The nucleus defends itself, producing interferons that instruct other cells to be alert against SARS-CoV-2 invaders. This mounts a good immune response.
After exposure, it can take from 2-14 days to get sick. Some have reported sickness after 28 days, and the mean average time is 5.1 days. Variability is related to one’s immune system.
This is key to understanding the dosing regimen for ivermectin. If it is dosed on Day #1, SARS-CoV-2 may be inactivated. However, in some people the virus does not start replicating until Day #3 or Day #14, which is why the second and third doses are spread apart.
Additionally, the half-life of ivermectin is 18 hours, so splitting the dose in two not only decreases side effects but also brings the opportunity to work against the virus for a long time and in different phases of the virus' life cycle.
Here is a link of a review of emerging evidence demonstrating the efficacy of ivermectin in both the prophylaxis and treatment of COVID-19. Properties of ivermectin are listed here and include the following:
· Ivermectin inhibits the replication of many viruses, including SARS-CoV-2 and the flu.
· It is anti-inflammatory and therefore may decrease pain.
· It decreases viral load and protects against organ damage in animals.
· When taken either pre- or post-exposure, ivermectin prevents COVID-19 transmission.
· It hastens recovery, decreases hospitalization and mortality in patients with COVID-19.
· Ivermectin leads to far fewer COVID fatalities in regions where it has been widely used.
The total number of studies done on ivermectin for COVID-19 include 27 controlled trials in 6,612 patients placed in well-matched control groups. There are 16 trials with over 2,500 patients in prospective, randomized, controlled studies. 11 of the 27 trials are published in peer-reviewed journals. An estimated 3,900 more patients have been in trials that are in press.
A meta-analysis by an independent research consortium calculated the chances that ivermectin is ineffective in COVID-19 to be 1 in 67 million. The FLCCC Alliance, based on evidence totality, supports an “A-1” recommendation in the NIH rating scheme, showing strong level, high-quality evidence in both the prophylaxis and treatment of all phases of COVID-19. Finally, multiple, population-wide ivermectin distribution program data show a significant reduction in cases and mortality rates.
There are two protocols for outpatients:
1) prophylaxis for when you are not yet sick, and
2) early treatment for when you are sick.
I-MASK+ PROPHYLAXIS: May repeat one dose every 1-2 weeks
Ivermectin
High-risk individual prophylaxis: 0.15 - 0.2 mg/kg per dose; one dose today, 2nd dose in 48 hours, then one dose every 1-2 weeks (this recommendation is constantly updated); for co-morbidities and the elderly. The half-life of ivermectin is 18 hours, which is why one day is skipped.
For 70 kg weight, one dose may be split into 6 mg twice a day. We highly recommend splitting the dose in two per day (i.e., every 12 hours) it is taken, because it lasts for 18 hours and by adding 12 hours to that, the dose is extended out to 30 hours to stop SARS-CoV-2, the COVID-19 virus, from multiplying itself.
After COVID-19 exposure prophylaxis: 0.2 mg/kg per dose; one dose today, then 2nd dose in 48 hours; use if a household member is COVID-19 positive, or for prolonged exposure. For 70 kg weight, one dose may be split into 6 mg twice a day.
I-MASK+ PROPHYLAXIS
Ivermectin: One tablet on Days #1 and #3, then one tablet every week
Melatonin 6 mg before bedtime for sleepiness
Ascorbic acid (Vitamin C) 1000 mg twice per day
Vitamin D3 + K2 1000 – 3000 IU per day Vitamin D3
Quercetin 250 mg per day (also drink green tea)
Zinc 50 mg per day
I-MASK+ EARLY OUTPATIENT PROTOCOL: May repeat one dose every 1-2 weeks
Ivermectin 0.15-0.2 mg/kg dose; one dose daily for at least 2 days; continue daily until recovered for a maximum of 5 days
Ivermectin: One tablet for 2-5 days, then 1-2 times per week
Melatonin 10 mg before bedtime
Ascorbic acid (Vitamin C) 2000 mg, 2-3 times per day
Vitamin D3 + K2 4000 IU per day
Quercetin 250 mg per day or may drink macha green tea (ECGC)
Zinc 100 mg per day
Aspirin 325 mg per day, unless contraindicated
Pulse oximeter: Watch for a downward trend. 94% saturation should be regarded as ominous and you should go to the hospital or call 911 for breathing difficulties
Home monitoring with pulse oximetry is recommended for COVID-symptomatic patients. Be aware that low oxygen levels can otherwise be impossible to detect, as the patient may have no hypoxic symptoms.
Home pulse oximeters have limitations and it is preferred to use a validated device. Take multiple readings throughout the day, watching for downward trends that require 911 or hospitalization. Most believe that a baseline less than 94%, or a saturation of 94% upon walking is a reason to hospitalize.
Warm a cold extremity and take off nail polish prior to using. Use the middle or index finger; avoid toes or the ear lobe. Only believe values that also give a strong light with each pulse, i.e., a strong pulse signal. Take a reading for 30-60 seconds, and use the most common number.
Supplements are regulated by the Food and Drug Administration (FDA) as a food. The Dietary Supplement Health and Education Act of 1994 allows that dietary supplement manufacturers do not need FDA approval; instead, the manufacturer is responsible to ensure their products are safe.
The FDA cannot test every product to ensure it does not contain potentially harmful additives or fillers, including cancer-causing ones. In the case of Vitamin D, beware that even if you are taking a vitamin D supplement, there may not actually even be any absorbable Vitamin D in it, and your blood level may still show an abnormally low level.
Additionally, Vitamin D needs help to be absorbed by the body. We recommend our patients use Vitamin D3 plus Vitamin K2, which helps increase absorption. If after 3 months of a good product your blood level does not go up, you may need a higher dose or absorbability, i.e., an injectable or topical route). To optimize absorption, take Vitamin D, a fat-soluble vitamin, after eating high-fat food or after a meal. In general, many doctors recommend taking 800 IU of Vitamin D3 per day.
Gut absorption is a factor in Vitamin D3 supplementation, because it is absorbed in the small intestine, just after passing the stomach. Things that influence absorption include stomach juices and pH, secretions from the pancreas and gallbladder, liver bile, and small intestine integrity. The following diagnoses can limit Vitamin D3 absorption: celiac disease, Crohn’s disease, cystic fibrosis, chronic pancreatitis, liver dysfunction, kidney disease, and gastroparesis. In end-stage kidney disease, Vitamin D levels are undetectable.
DISCLAIMER:
The I-MASK+ Prophylaxis & Early Outpatient Treatment Protocol for COVID-19 and the MATH+ Hospital Treatment Protocol for COVID-19 are only for informational and educational purposes, and is not medical advice. Never disregard professional medical advice due to something you read on the internet. This is not intended to be a substitute for professional medical advice, diagnosis, or treatment in regards to any specific patient. Treatment for an individual patient should always rely on the judgement, opinion, and advice of your personal physician or other qualified health provider. Always seek their specific advice with your questions about your health or medical condition.
NOTE: Dr. Aranda may receive a small commission on Metagenics supplements purchased from this website.
REFERENCES
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Arévalo AP, Pagotto R, Pórfido J, et al. Ivermectin reduces coronavirus infection in vivo: a mouse experimental model. bioRxiv. 2020; Preprint.
Callan N, Hanes D and Bradley R. Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain. J Transla Med 18:401. Oct 21, 2020.
Caly L, Druce JD, Catton MG, Jans DA and Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research 178, 104787, June 2020.
Campbell WC, Fisher MH. Stapley EO, Albers-Shönberg G, Jacob TA. Ivermectin: a potent new antiparasitic agent. Science. 1983 Aug 26; 221(4613): 823-828.
Chamie-Quintero, J and H, J and Scheim, D. Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments (January 12, 2021). SSRN Jan 21, 2021.
Crump A. Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations. J Antibiot (Tokyo). 2017 May; 70(5):495-505.
Deire P, Caporuscio F, Saviano M, Mangiatordi GF. Repurposing known drugs as covalent and non-covalent inhibitors of the SARS-CoV-2 papain-like protease. Front Chem. Nov 16, 2020.
DiNicolantonio JJ, Barroso J, McCarty M. Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19. Open Heart. 2020;7(2).
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Gradišar, H, Keber MM, Pristovšek P and Jerala R. MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukocyte Biol 82, 968-974, 2007.
Hahn H, Kim S-J, Choi B-Y, Cho K-C, Bandu R, Kim KP, et al. Curcumin interacts directly with the cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells. Sci Rep. 8:6409; 2018.
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Khan MSI, Khan MSI, Debnath CR, et al. Ivermectin treatment may improve the prognosis of patients with COVID-19. Arch Bronconeumol. 2020;56(12):828-830.
Kory, P, Meduri GU, Iglesias J, Varon J, Berkowitz K, Kronfeld H, Vinjevoll E, Mitchell S, Wagshul F, and Marik, PE. Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19. FLCCC Alliance; updated Jan 12, 2021.
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Aranda MD Enterprises wants to keep you in the family. After you have suffered from a post-viral syndrome like COVID-19, lower back pain, adrenal or other hormone issues, we can help.
Dr. Margaret Aranda is a Keck-USC and Stanford-trained anesthesiologist with subspecialty training in critical care. Her PhD is in forensic science; her thesis was on women's health. After doing operating room and intensive care at the University of Pennsylvania, she was Assistant Professor in three departments: Anesthesiology and Critical Care, Surgery and Traumatology, and Radiology. As Interim Chief of Anesthesiology at the University of Pennsylvania's Philadelphia VA Medical Center during 911, she optimized veteran's health care outcomes and spearheaded several patient protocols.
Dr. Aranda has been practicing medicine in Los Angeles for over two years. Her services include pain management in a caring manner for patients with a type of chronic pain that is never going to change, age management, weight control, hair loss, and regenerative medicine. Her seventh book will center on the management of failed back syndrome and describe her current protocol that patients and physicians can understand.
Now a traumatic brain injury survivor after a tragic accident with her daughter, Dr. Aranda understands pain and disability. She has personal insight into rejuvenating you back to a your best possible health. Her most recent publication is The Rebel Patient™ book.
Dr. Margaret Aranda is a member of the following Societies:
Invisible Disibilities™ Association, Vice Chair
American Medical Association, Member
American Society of Anesthesiologists, Member
California Society of Anesthesiologists, Member
Tucked away in the mountains of southern California, Dr. Aranda is a devoted mother of two who stays active writing, cooking, and training Buddha, her relaxed German Shepherd.
If you would like to be a patient and receive ivermectin (IVM), click the blue button below. You will be directed to our electronic medical record. Fill in your name, email address, street address, phone number and birthdate. Follow the prompts to finish, and you will be waiting in our docket for a call, text, or email.
The cost of your appointment is $200, which includes sending your IVM prescription to a pharmacy.
Please send it to info@ArandaMDenterprises.com
But wait! Also get some equipment for your home health - you will need it for telemedicine appointments. You will also need this equipment in case you get sick, so it is best to have them now. Go ahead and see Step 3.
Thermometer
Blood pressure cuff (sphygmamometer)
Pulse oximeter (does % oxygen saturation and your heart rate)
In the same email with your CA driver's license, give us a picture of the following:
1. Your temperature reading
2. Your blood pressure reading
3. Your pulse oximeter reading (it includes your heart rate)
4. Your heart rate
5. Your height
6. Your weight - this must be accurate, because IVM is dosed in milligrams per pound
See Step 4 and then email us everything.
We also need to know the following:
A. Medical Problems
B. Surgeries (List year and date)
C. Medications (name, dose, frequency)
D. Allergies
Once you are talking to the doctor, she will ask for more information.
When you Pre-Register, your name and contact information will be sitting in our docket. We will connect with you to complete your chart, and then Dr. Margaret Aranda will call you to finalize your prescription. While waiting for her call, you have a little homework...
You may find a pharmacy near you that has ivermectin, 3 mg tablets, about 2-3 boxes (they come in a box of 20). We find they usually have only 1-2 boxes and we are not sure that they will be good at refilling every 3 months when you run out of tablets. Some find their insurance will pay for it. Others like to use GoodRx for a good discount on a coupon.
If you have trouble finding a pharmacy, no worries. We have a pharmacy that can hand-mix your exact dose and ship it to your door.
If you find a local pharmacy, we need their contact information. Send us an email with their name, address and phone number. Thank you for your patience as we find their special code needed to receive our electronic prescription.
For Step 7, you need to decide how you want to use it:
1) Prevention with low risk;
2) Prevention with high risk; or
3) Outpatient treatment for when you are sick
This is an important decision to make, so talk to your family and weigh not only how you want to use ivermectin, but also your exposure risk, the number of tablets in your hand, your budget, and perhaps most importantly, how you will be able to get refills for when/if it runs out.
No matter which decisions you make, we are here to help guide you.
The dose for ivermectin is different for every one, because it is based on your weight. The more you weigh, the faster you will go through boxed tablets. If you compound the medication for your exact weight, it is easier because each day is one capsule. If you buy a box of 20 tablets, you will be breaking opened several blister packs and getting them out of the packaging, which can be moderately difficult for those with arthritis.
There are 3 basic ways to prescribe ivermectin according to the I-MASK+ Protocol:
If you just want to have it in your hand in case you get sick, we recommend #3. This way, you have a good quantity of tablets and you can be treated at home without going to the hospital. If you change your mind and decide to use ivermectin for prophylaxis, you can still do that, and you will have enough tablets to last a while. See our chart below on how long each dosing. regimen lasts for your weight.
If you decide you just want the low-dose prevention, you cannot count on having enough in hand to take, should you become sick with COVID-19. If you have a low budget, #1 is the best way to go because for the least amount of money, you can stretch out a handful of doses to last a long time.
We like to prescribe 20 doses.
For #1 dosing at Prevention, you have enough for 39 weeks, or 9.75 months.
For #2 dosing, where you start at Prevention and get sick somewhere in that 39 weeks, you increase the dose and frequency to #3. Depending on when you get sick, and how long it takes to get better, the same number of doses can last you 2-9 months.
For #3 dosing, you can start Outpatient Treatment on Days #1 and #3, then dose 2x/week for 6 weeks.
Most like to start #1, the Prevention or Prophylaxis dose, then keep at least 5 doses in your hand, in case you get sick and want to take 2-5 days, or. 2-5 doses.
When you talk to the doctor and your prescription is written, you will know how long it will last because she will tell you. If you forget, you can simply read the bottle label and it will say the number of days it lasts.
Before your appointment, you can get an idea of how long all 3 different kinds of prescriptions last. Remember that the 3 different prescriptions are:
1) Prophylaxis = Prevention, low-dose for you when you are not exposed and not near anyone sick with COVID
2) Exposure = Prevention, high-dose for when you are exposed or near someone who is positive
3) Outpatient Treatment for when you are sick with COVID
This is how to determine how many pills or tablets you will have, and how long it will last:
Remember that no one is advocating ivermectin use by itself. The I-MASK+ protocol utilizes supplements like vitamins D and C, quercetin and Zinc. Please review the protocol and boost your immune system, as recommended by the protocol.
Americans are used to weight in pounds (lb).
To calculate your dose by pounds of weight, we find your weight in pounds on the chart.
Then we either:
1) divide your dose by 3 to know how many tablets you take per day, or
2) use that dose to write orders for the pharmacy to "compound" or hand-make your capsules.
Remember that no one is advocating ivermectin use by itself. The I-MASK+ protocol utilizes supplements like vitamins D and C, quercetin and Zinc. Please review the protocol and boost your immune system, as recommended by the protocol.
All over the rest of the world, we use weight in kilograms (kg).
To calculate your dose by kilograms of weight, we find your weight in kg on our chart.
Then we either:
1) divide your dose by 3 to know how many tablets you take per day, or
2) use that dose to write orders for the pharmacy to "compound" or hand-make your capsules.
Remember that no one is advocating ivermectin use by itself. The I-MASK+ protocol utilizes supplements like vitamins D and C, quercetin and Zinc. Please review the protocol and boost your immune system, as recommended by the protocol.
After you tell us which of the 3 dosing regimens you want on hand, we see how many doses and for what period of time your ivermectin prescription needs to be written.
To further individualize it for your exact weight, we go back up to the tables above to get a more exact prescription written for you.
Remember that no one is advocating ivermectin use by itself. The I-MASK+ protocol utilizes supplements like vitamins D and C, quercetin and Zinc. Please review the protocol and boost your immune system, as recommended by the protocol.
Do we write refills?
Not right now. When your doses run out, we want you to come back. No one has ever written for ivermectin before, so we want to know how you did, if the dose was too strong, if you lost or gained weight. After we assess your reaction(s) to ivermectin, we plan your current needs, formulate your dose, and determine how many doses you need.
Remember that the dose can be split in half. So if you are on tablets, you can take 1/2 of them in the morning and the other half 12 hours later, completing one day's dose. If you have compounded capsules, the only way to split the dose in half is to open the capsule, pour it in orange juice, then drink 1/2 of it in the morning and 1/2 of it 12 hours later.
The advantage of splitting the dose in half is for when the virus is in your body and replicating, or multiplying itself. The morning dose may target older virus particles and the evening dose may target younger ones that just started multiplying. Splitting the dose offers the unique advantage of targeting virus particles in different life cycles, and may be better at ridding you body of it.
If you take ivermectin every 12 hours, this may also decrease the common side effects. At any rate, take it at the time you are supposed to take it. Do not miss a dose and take it on time. - set an alarm if needed.
If your dose of ivermectin is, for example, 6 mg for one day, you would simply take 3 mg at 7 am and 3 mg at 7 pm.
Side effects. Since ivermectin kills parasites, the side effects are bound to be different than seen with other usual drugs. The more stomach or intestinal side effects you have, the more likely you have parasite toxins or debris. Ivermectin works through the bile and stool excretion, so it makes sense that the most common side effects are in the gut and stool.
Common side effects. The most common side effects have to do with your gut and do not usually require medical attention. If you have river blindness or a parasite infection, ivermectin will cause parasites to die, releasing debris and toxins into your gut; they come out your stool. Here are common side effects:
Because of these common side effects, we recommend you take your loading doses on Days #1 and #3 about a week before you hop on a plane or go on a trip. It may be best to complete these two doses one week prior to a long trip, as you may need to frequently or suddenly use the restroom.
Uncommon side effects. These may require medical attention; tell your doctor of you experience:
At-Risk Individuals. If you have a lot of allergies to many different drugs, you are at high risk of having an allergic reaction to ivermectin. That does not mean you cannot take it; It means you may have to decrease the dose, split it, pre-medicate before taking it, and/or have an EpiPen available in case of anaphylaxis. For example, you could also have on hand: Benadryl or diphenhydramine, an EpiPen, and methylprednisolone steroid. You may also have to call 911 if your lips or tongue begin to swell, or if you have breathing problems. For these reasons, you should not be alone when you take it, you may want to first take a very small fraction of a "test dose" and whoever is with you should be familiar with your medical problems and assist with calling for help.
Seizures. If you have a history of seizures, it is safest to assume you are at some increased risk of having a seizure on ivermectin. As with allergies above, that does not mean you cannot take it; it means you may have to decrease the dose, split it, and pre-medicate for seizures before taking it. You should not be alone, you may want to first take a very small fraction of a "test dose" and whoever is with you should be familiar with your seizure history and drugs that work for you, and also assist with calling for help.
Pregnancy and Nursing. Pregnant and nursing women have safely used ivermectin without harm on their babies. Some have used it to treat the baby, who gets a reduced dose through breast milk. Talk to your doctor, as this is not meant to be medical advice.
Beneficial Side Effects. Some report feeling sleepy on ivermectin, and take the dose at bedtime. Because ivermectin is anti-inflammatory, some report decreased pain, as in the knee pain of osteoarthritis. Others have reported bright green stool, again probably from parasite debris. Plan to take your first Day #1 and #3 doses on a weekend or when you have a couple of days off. You may be using the restroom more frequently than usual.
Remember that no one is advocating ivermectin use by itself. The I-MASK+ protocol utilizes supplements like vitamins D and C, quercetin and Zinc. Please review the protocol and boost your immune system, as recommended by the protocol.
Melatonin has been used for insomnia and correcting the circadian rhythm, depression, and drug addiction. It has also been shown to have effects that are anti-inflammatory, anti-oxidant, and enhancing the immune system. That is why it is on the I-MASK+ Protocol. In animal studies, it lowers the same cytokines that cause COVID-19 related lung injury. It also blocks the lung fibrosis associated with severe COVID-19.
Doctor and scientist Sanjay Sethi, MD and a group of internationally-known doctors at the University at Buffalo (UB) started a clinical study on melatonin in September, 2020, that looks at the role melatonin may play in reducing COVID-19 complications. They have a compendium of expertise in the fields of brain research on melatonin, pulmonary and infectious disease. Margarita Dr. Sethi is co-investigator in the study.
The FDA approved a pilot study in only 30 patients that undergo Dr. Sethi's research using melatonin under a special research provision, as an Investigational New Drug. They are looking primarily at safety; this will provide a basis for further research. You can even participate in melatonin research here.
We like a proprietary blend of melatonin called Benesom(R) from Metagenics, a company that makes physician-grade supplements and one that Dr. Aranda uses (please note she may get a small commission from your purchase). One serving size is 2 tablets and it includes:
Melatonin, 3 mg
Magnesium citrate, 140 mg
Calcium lactate 70 mg
Chinese skullcap, 400 mg
Passionflower, 200 mg
Melissa lemon balm, 150 mg
Valerian root extract, 100 mg
Hops, 50 mg
Because of the other supplements listed, use caution if you are also on: sedatives, hypnotics, benzodiazepines, blood thinners, or have depression or a history of seizures. If you have severe sleep difficulties, talk to a doctor about re-establishing a circadian rhythm with day:night cycles.
Seventy-five percent of all colds are caused by a coronavirus. Vitamin C is a potent anti-inflammatory and anti-oxidant that is crucial to the immune system. A large study of 11,000 patients found that vitamin C decreases your risk of catching a cold in the first place. If you do catch a cold, it isn't too late - vitamin C also reduces your symptoms like runny nose and headache.
If you are low on iron and take iron supplements, be sure to take iron with vitamin C, which increases the absorption of iron.
Besides being anti-oxidant, vitamin C supports the immune system and is essential for the production of connective tissue and collagen, which supports skin, hair, bones, ligaments, tendons, and gums. We like a proprietary Metagenics(R) chewable Vitamin C that contains as much vitamin C as eating 4 oranges.
NOTE: Dr. Aranda may get a small commission from purchases made on the Metagenics website.
After iron, zinc is the second most common trace metal found in every cell in your body. Zinc is also a potent anti-inflammatory mineral that is essential for:
Zinc is more than that to the novel coronavirus. It it thought to bind to the SARS-CoV-2 spiked protein, preventing it from replicating its genetic material.
As with vitamin D, the zinc supplement you take matters because it has to be absorbed through the gut. To determine if you are zinc deficient, Metagenics has a Zinc Tally(TM) test solution - if you can taste it right away, your zinc level should be fine. If you cannot taste it, you may be deficient even though you are on a supplement.
We like either
1) a liquid zinc sulfate drink you add to water or juice for increased gut absorption, or
2) a gut-friendly, highly absorbable zinc tablet chelated with the amino acids arginine and glycine
James A. Robb, MD, pathologist and virologist from the University of Colorado School of Medicine recommends using zinc lozenges and letting them dissolve at the back of the upper back of the throat, near the nose.
In 2009, the FDA recommended against using a nasal zinc spray, because it caused some patients to lose their sense of smell.
NOTE: Dr. Aranda may get a small commission from purchases on the Metagenics links.
Patients low on vitamin D were found to have an increased chance of being hospitalized or dying. Nations having many patients low on vitamin D had increased outbreaks and higher death rates. Elderly men in nursing homes with low vitamin D and low testosterone levels were more likely to die.
Vitamin D boosts the immune system, and many patients cannot count on getting enough vitamin D from the sun. If you are concerned, talk to your doctor about testing your blood vitamin D level. While taking too much vitamin D is not beneficial, most believe it is better, in the COVID environment, to have higher rather than lower levels.
You must take a good vitamin D, preferably D-3 plus vitamin K-2 that increases its absorption. We prefer physician-grade supplements found at Metagenics(R).
Quercetin has a molecule called ECGC, a potent anti-inflammatory found in high concentrations in green tea. Quercetin binds to the coronavirus' spiked proteins, preventing it from infecting cells.
NOTE: Dr. Margaret Aranda may get a small commission from products purchased on her Metagenics website.
To understand how COVID-10 vaccines work, one needs to understand how the immune system works. The immune system is called into action when the body is invaded by germs. While red blood cells and platelets work to provide blood supply and oxygen to tissues, platelets stop bleeding from cuts. The following cells are involved in mounting an immune response against germs: macrophages, B-lymphocytes and T-lymphocytes. Macrophages digest dead germs and debris, B-cells make antibodies that attach to germ pieces left by macrophages. T-cells attack the body's cells that got infected.
If the same germ comes back into the body, T-cells "remember" the germ and mount a stronger attack.
While COVID-19 vaccines may differ in how they are made, all create specific B and T-cells that "remember" COVID-19. It usually takes the body 2-3 weeks to generate these T and B cells, during which time you may still be able to get the illness. After the vaccine, a fever and muscle aches are a sign that the body has mounted an immune response.
After the last booster vaccine in the series, the time for the vaccination to work varies person to person. In general, it takes about 1-2 weeks for your body to develop antibodies.
Keep wearing your mask, stay 6 feet away from others, avoid touching your face or eyes, and wash your hands frequently.
Getting the vaccine does not mean you can stop being cautious. Keep all the same precautions.
Again, it varies person to person. And no one really knows, because not enough time has gone by. In general, it is thought the vaccine may offer protection against a form of COVID for 5 - 12 months.
There are geographic areas having more serious and deadly mutations of SARS-CoV-2 virus mutations. These areas include:
South Africa: variant 20H/501Y.V2 or B.1.351 and E484K.
The UK: variant 20I/501Y.V1, VOC 202012/01, or B.1.1.7.
Brazil: P.1 and E484K. This mutation increases resistance to several COVID vaccines by 3 x, and 10 x resistance to most convalescent antibodies.
California: B.1.427 and B.1.429 or CAL.20C, or 20C/S:452R;/B1429, a different mutation scheme, having a 4.8 x risk of an ICU stay and an 11 x increased risk of death. It impacts antibody effectiveness: it was 4 x less susceptible than coronavirus to neutralize antibodies from people who recovered from COVID-19, and 2 x less susceptible to antibodies from the blood of people vaccinated with the Pfizer or Moderna vaccines.
So far, the California mutation has been identified in 19 states and Washington, DC, as well as in six other countries.
Nigeria: variant B.1.525. It has also been found in the United Kingdom, France, and elsewhere. It may increase transmissibility, virulence, and escape from immunity.
Since the vaccinations are made against a particular form of the virus, it is thought to have diminished effectiveness against other strains or mutations.
What does this mean for you? It means that just because you get the vaccination, you do not have a 100% chance of immunity to more lethal mutations. Since ivermectin is not dependent on just one mechanism or way to protect you, it will work in many different ways against any mutations. Most believe that in these areas or in any case of mutation, it is worthwhile and adds protection to also take ivermectin, even if you already had the vaccination, and even if you already had coronavirus infection.
Many believe ivermectin will become the standard of care against COVID-19 and future strains, including Dr. Pierre Kory, President and CEO of the Front Line COVID-19 Critical Care (FLCCC) Alliance.
For those who have not taken the vaccination, ivermectin may be taken as in the I-MASK+ protocol. If you start ivermectin on Day #1, you may take the vaccination on Day #2, then take the 2nd dose of ivermectin on Day #3. Perhaps this leaves you best protected.
Information on the vaccinations is constantly being updated by the Centers for Disease Control (CDC). For those who do not want to take the vaccine due to personal or religious beliefs, ivermectin is an excellent choice to either prevent or treat COVID.
The first thing to know is that in the clinical studies testing the vaccinations, patients with anaphylaxis were not included, due to the increased risk of anaphylaxis and death.
Common risks of virtually all vaccinations include a sore arm, fever, chills, headache, nausea, myalgia, rash, the development of an autoimmune disorder like Systemic Lupus Erythematous (SLE) and Postural Orthostatic Tachycardia Syndrome (POTS). Severe risks of the COVID vaccines include clotting problems, anaphylaxis and death. If you have an allergic reaction to the first vaccine, most recommend you do not take the second vaccination.
For example, if anaphylaxis occurs and especially if the tongue or lips swell or if breathing problems occur, an emergency epinephrine or an EpiPen® may need to be immediately given to prevent your throat from closing. This leads to suffocation, a life-threatening matter.
One 56-year old doctor died after the vaccination, after going into ITP, a clotting disorder. Others with allergies, especially anaphylaxis, may also have anaphylaxis against the vaccine and these individuals should not get the vaccination. At the very least, they should carry the EpiPen to get the vaccine. If you don't have an EpiPen for airway issues, you should immediately call 911.
If you end up using an EpiPen, the allergic reaction may last longer as the pen wears off. In this case, many advocate starting a steroid to decrease inflammation and swelling around the airway.
Another patient died after the Pfizer injection in Belgium. It is unknown whether the vaccine played a role and an autopsy is pending in Belgium.
Finally, if you get a sore arm or other mild reactions to the vaccination, that is considered to be a good thing, as your immune system. is triggered.
Messenger RNA (mRNA): Moderna or Pfizer. The Moderna or Pfizer-BioNTech vaccines use mRNA for the spiked protein. It goes into the cell’s ribosomes, which then produce more spiked protein. The spiked protein is then transferred outside the cell and inactivated. Ivermectin cannot change or modify this chain reaction, so ivermectin will continue to be active.
Adenovirus vaccination: AstraZenica. The AstraZenica vaccine is a spiked COVID virus attached to adenovirus. It arrives in the cell, and its spikes dissolve. It causes the inner part of the virus to come out, allowing the adenovirus to connect and cross into the nucleus. It then injects DNA into the nucleus. Ivermectin cannot stop this, so the adenovirus-based vaccines may be safely taken together with ivermectin. Because ivermectin is also anti-inflammatory, if you are already on ivermectin and then you take the vaccine, you may have fewer inflammatory side effects like a swollen arm.
Sinovac. The Sinovac vaccination has not compiled a comprehensive review of their own data.
Both mRNA and adenovirus vaccines act differently than ivermectin. Ivermectin continues to be protective against the actual virus, while the vaccine uses the body’s immune system.
Moderna and Pfizer mRNA vaccines were each studied in large groups of 15,000 – 19,000 people given vaccine, and the same amount given placebo. The Pfizer vaccine was studied to show that post-vaccine, the highest antibody levels occur at Day 7. If your antibody levels are zero on Day 7, your body may still be making them and the test can be repeated in 7-10 days. If your body undergoes the cytotoxic pathway, you may not generate antibodies. Usually, the antibody levels continue to go up for about 30 days.
The Lancet medical publication reported on the Safety and Efficacy of the ChAdOx1 nCoV-19 vaccine, the AstraZenica adenovirus vaccine in two populations each, those given two doses of vaccine and those given placebo. Findings in Brazil show only 4,088 people studied and in the UK, 7,548 people were studied with the vaccine showing about 70% efficacy. There is an ongoing trial in the US to study the AstraZenica vaccine in a larger group of people.
After a SARS-CoV-2 virus infection, many experience a feeling of chronic fatigue and severe tiredness that can sap all energy and render one bedridden. It can last for months and months, dragging along with no seeming end in sight.
This kind of fatigue makes one long for better days and seeing the world in vivid colors again.
This is also known as a post-viral syndrome. It is real, and takes a great deal of patience to treat.
Caring for these "complicated" patients really is not complicated. They all have the same things: chronic fatigue, depleted energy, bedridden or severely limited physical status, inability to exercise due to worsened fatigue, loss of sexual enjoyment, and possibly some depression or anxiety, or both. Chronic pain may be implicated as well.
It is super important to first determine all the variety of diagnoses that go along with post-viral syndrome. Patients need a blood draw. As one problem here and one problem there is diagnosed, it may be that for a time, you simply stop getting worse. Months later, you may start feeling better, or much better.
These are the kinds of diagnoses one may find with post-viral syndrome:
Epstein-Barr positive serum
Chronic fatigue syndrome
Fibromyalgia
Systemic lupus erythematous
Anemia
Chronic pain
Electrolyte imbalance
Vitamin D deficiency
Insomnia and loss of day:night cycles
Loss of sexual libido
Hypothyroidism
Panhypopituitarism
Hypogonadism, a lack of sex hormone production
Adrenal fatigue or failure, a lack of cortisol stress hormone
Hypercholesterolemia
Pre-diabetes
Kidney dysfunction
Dysautonomia
Anxiety due to multiple medical conditions
Depression
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